November 12, 2004

GAY PEOPLE'S CHRONICLE 11

• Serious liver problems (hepatotoxicity), with liver enlargement (hepatomegaly) and fat in the liver (steatosis), may occur. Call your medical professional right away if you have light colored stools, dark colored urine, and/or if your skin or the whites of your eyes turn yellow.

• Flare-ups of hepatitis B virus infection (HBV): If you have HIV and HBV, your liver disease may suddenly get worse if you stop taking TRUVADA. Do not stop taking TRUVADA unless directed by your medical professional.

• Kidney problems: If you have had kidney problems or take other medicines that can cause kidney problems, your medical professional should do regular blood tests to check your kidneys.

• Bone changes: It is not known whether long-term use of TRUVADA causes damage to your bones. If you have had bone problems in the past, talk to your medical professional before taking TRUVADA.

Changes in body fat have been seen in some people taking anti-HIV medicines. The most common side effects of TRUVADA when taken with other anti-HIV medicines are dizziness, diarrhea, nausea, vomiting, headache, rash, and gas. Skin discoloration (spots and freckles) may also occur. Discuss all medicines you take with your medical professional and be aware:

• TRUVADA should not be used with Combivir®, Emtriva, Epivir, Epivir-HBV®, EpzicomTM, TrizivirR, or Viread.

• Your medical professional may need to follow you more closely or adjust your therapy if you are taking Videx®, Videx EC®, ReyatazTM or KaletraR with TRUVADA.

There is additional information about TRUVADA on the next page.

Truvada is a trademark of Gilead Sciences, Inc.

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